Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events.

نویسندگان

  • Yue Li
  • Rie Uenishi
  • Saiki Hase
  • Huanan Liao
  • Xiao-Jie Li
  • Takayo Tsuchiura
  • Kok Keng Tee
  • Oliver G Pybus
  • Yutaka Takebe
چکیده

We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region.

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عنوان ژورنال:
  • Virology

دوره 402 2  شماره 

صفحات  -

تاریخ انتشار 2010